Issued heat shock protein (HSP) patents
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| US Patent No. |
Date Issued |
Coverage |
| 7,186,515 |
Mar. 6, 2007 |
Methods for identifying compounds (including antibodies) that modulate the interaction of HSPs with the HSP receptor, CD91. |
| 7,179,462 |
Feb. 20, 2007 |
Methods of treating autoimmune diseases with anti-CD91 antibodies. |
| 7,132,109 |
Nov. 7, 2006 |
Method of treating cancer with generic HSP in combination with a cancer vaccine. |
| 6,984,389 |
Jan. 10, 2006 |
Method of treating cancer with HSP-peptide complexes in combination with tyrosine kinase inhibitors (like Gleevec). |
| 6,797,480 |
Sept. 28, 2004 |
Methods for screening molecules for the
ability to modulate heat shock protein receptor activity. |
| 6,610,659 |
Aug. 26, 2003 |
Compositions of peptides that are eluted
from HSP70 isolated from mammalian tumor cells |
| 6,475,490 |
Nov. 5, 2002 |
Methods of promoting healing of skin wounds
by administering purified heat shock proteins (HSPs) or
HSP-peptide complexes |
| 6,468,540 |
Oct. 22, 2002 |
Composition of HSP-peptide complexes isolated
from tumors of household pets |
| 6,461,615 |
Oct. 8, 2002 |
Treating or preventing infectious diseases
by administering HSP-antigen complexes that are made in
vitro |
| 6,455,503 |
Sept. 24, 2002 |
A composition of peptides that are eluted
from HSPs isolated from pathogen-infected cells and a composition
of such eluted peptides and an adjuvant |
| 6,455,048 |
Sept. 24, 2002 |
Methods of preventing cancer with doses
of HSP70 below 10 micrograms |
| 6,451,316 |
Sept. 17, 2002 |
Methods of using HSP-peptide complexes to
expand antigen-specific T cells in vitro |
| 6,447,781 |
Sept. 10, 2002 |
Methods of preventing cancer using HSPs
complexed to antigens in vitro |
| 6,447,780 |
Sept. 10, 2002 |
Methods of preventing cancer with doses
of HSP90 below 50 micrograms |
| 6,436,404 |
Aug. 20, 2002 |
Methods of preventing cancer with doses
of gp96 below 10 micrograms |
| 6,410,028 |
June 25, 2002 |
Methods of eliciting immune response using
HSPs complexed to proteins or peptides in vitro |
| 6,410,027 |
June 25, 2002 |
Medical applications of HSPs in patients
with small tumors |
| 6,410,026 |
June 25, 2002 |
Medical applications of HSPs in patients
with small tumors |
| 6,406,700 |
June 18, 2002 |
Methods of preventing cancer using HSPs |
| 6,403,095 |
June 11, 2002 |
Methods of treating cancer with doses of
HSP70 below 10 micrograms |
| 6,399,070 |
June 4, 2002 |
Methods of eliciting immune response with
doses of HSP90 below 50 micrograms |
| 6,399,069 |
June 4, 2002 |
Methods of preventing infectious diseases
with doses of HSP70 below 10 micrograms |
| 6,391,306 |
May 21, 2002 |
Methods of treating infectious diseases
with doses of HSP90 below 50 micrograms |
| 6,387,374 |
May 14, 2002 |
Methods of treating cancer with doses of
HSP90 below 50 micrograms |
| 6,383,494 |
May 7, 2002 |
Methods of eliciting immune response with
doses of gp96 below 10 micrograms |
| 6,383,493 |
May 7, 2002 |
Methods of eliciting immune response with
doses of HSP70 below 10 micrograms |
| 6,383,492 |
May 7, 2002 |
Methods of treating infectious diseases
with doses of gp96 below 10 micrograms |
| 6,383,491 |
May 7, 2002 |
Methods of preventing infectious diseases
with doses of HSP90 below 50 micrograms |
| 6,379,672 |
Apr. 30, 2002 |
Methods of preventing infectious diseases
with doses of gp96 below 10 micrograms |
| 6,375,953 |
Apr. 23, 2002 |
Methods of treating infectious diseases
with doses of HSP70 below 10 micrograms |
| 6,322,790 |
Nov. 27, 2001 |
Method of eliciting immune response by administering
HSP-antigen complexes in combination with dendritic cells
that were previously sensitized with HSP-antigen complexes
in vitro. |
| 6,187,312 |
Feb. 13, 2001 |
Methods of treating or preventing infectious
diseases with low doses of HSP90 |
| 6,168,793 |
Jan. 2, 2001 |
Methods of eliciting immune response and
treating cancer or infectious diseases with HSP70 |
| 6,162,436 |
Dec. 19, 2000 |
Methods of treating cancer with low doses
of HSP90. |
| 6,156,302 |
Dec. 5, 2000 |
Methods of preventing and treating infectious
diseases with antigen presenting cells sensitized in vitro
with HSP-antigen complexes. |
| 6,143,299 |
Nov. 7, 2000 |
Methods of treating or preventing infectious
diseases with low doses of gp96. |
| 6,139,841 |
Oct. 31, 2000 |
Methods of treating or preventing infectious
diseases with low doses of HSP70. |
| 6,136,315 |
Oct. 24, 2000 |
Methods of treating cancer with low doses
of HSP70. |
| 6,048,530 |
Apr. 11, 2000 |
Methods of preparing compositions of HSPs
complexed to pathogen-derived peptides. |
| 6,030,618 |
Feb. 29, 2000 |
Compositions of HSPs and antigenic peptides
(from cancers or pathogens) that are complexed in vitro as
well as methods of eliciting immune response with the compositions |
| 6,017,544 |
Jan. 25, 2000 |
Methods of treating cancer and eliciting
an immune response with mammalian HSP-peptide complexes
in combination with cytokines. Also covers compositions
comprising HSPs and cytokines. |
| 6,017,540 |
Jan. 25, 2000 |
Methods of treating cancer with doses of
gp96 below 10 micrograms |
| 6,007,821 |
Dec. 28, 1999 |
Method of treatment of autoimmune diseases
such as diabetes and multiple sclerosis with mammalian
HSPs. |
| 5,997,873 |
Dec. 7 1999 |
Methods of preparing noncovalent complexes
of HSPs and peptides from tumor tissue or from pathogen-infected
cells |
| 5,985,270 |
Nov. 16, 1999 |
Methods of preventing and treating cancer
with antigen-presenting cells sensitized in vitro with
HSP-antigen complexes that are purified from individual
patients' tumors |
| 5,961,979 |
Oct. 5, 1999 |
Nonautologous complexes of HSPs and antigenic
peptides produced in vitro as well as methods of
treating infectious diseases with HSP-peptide complexes
purified from pathogen-infected cells. |
| 5,948,646 |
Sept. 7, 1999 |
Methods of producing unlimited quantities
of HSP-peptide complexes from small tumor samples |
| 5,935,576 |
Aug. 10, 1999 |
Methods of treating cancer with any HSP
that is complexed in vitro with a tumor antigen |
| 5,837,251 |
Nov. 17, 1998 |
Methods of preventing and treating all types
of cancer and methods of eliciting tumor-specific immune
response using lower than expected doses of HSPs |
| 5,830,464 |
Nov. 3, 1998 |
Methods of preventing and treating cancer
with antigen-presenting cells sensitized in vitro with
HSP-antigen complexes that are purified from individual
patients' tumors. |
| 5,750,119 |
May 12, 1998 |
Methods of treating all types of cancer
and methods of eliciting tumor-specific immune response
using all mammalian HSPs (including HSP70-, HSP90- and
gp96-antigen complexes) as well as compositions of tumor-derived
HSP-antigen complexes. |
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