Kidney cancer

What is kidney cancer?
Kidney cancer is an abnormal, uncontrolled growth of cells
in the kidney.
According to the American
Cancer Society, the most common type is renal cell cancer
(also called renal cell carcinoma), which accounts for
85 percent of all kidney tumors.
Renal cell cancer may develop in one or both kidneys. In the
early stages, kidney cancer usually causes no obvious signs
or symptoms. As kidney cancer grows, it may invade organs near
the kidney such as the liver,
colon
or pancreas.
Kidney cancer cells may also break away from the original tumor
and spread (or metastasize) to other parts of the body
such as the lymph
nodes, bones or lungs, with about one third of cases showing
metastasis
at the time of diagnosis.
How many people get kidney cancer?
The American Cancer Society predicts that there will be about
51,190
new cases of kidney cancer in the United States
this year, with almost 12,890 people dying from the disease.
What causes kidney cancer?
The exact cause of renal cell cancer is not known. However,
certain risk factors are known to be associated with it, including
smoking, overuse of certain painkillers, long-term dialysis,
exposure to asbestos
or cadmium,
being overweight and eating a diet high in fat. In addition,
some genetic factors and diseases such as tuberous
sclerosis may increase ones risk. Renal cell carcinoma
typically occurs in people over the age of 50 and is twice as
likely to occur in men than in women.
How is kidney cancer diagnosed?
In most cases, renal cell cancer is found only after a person
has some sort of symptom of a problem. Because there are no
blood or urine tests to specifically screen for renal cell cancer,
it is sometimes found by accident when a person is having tests
for something else.
Blood in the urine is the most common sign of kidney cancer,
although this may also be caused by a bladder infection or some
other less serious condition. Signs and symptoms of renal cell
carcinoma can include:
- Blood in the urine
- Low back pain that is not caused by an injury
- Mass or lump in the abdomen
- Tiredness/fatigue
- Rapid, unexplained weight loss
- Fever that is unrelated to a cold, the flu or other infection
- Swelling of ankles and legs
- High blood pressure
These symptoms can also be caused by noncancerous conditions,
but only your doctor can tell for sure. If there is any reason
to suspect kidney cancer, the doctor will take your medical
history, conduct a physical exam and may perform imaging tests
such as CT
scan, MRI
or ultrasound
to produce a detailed picture of the inside of the body. Laboratory
tests such as urine and blood tests may also be performed to
check for problems that may occur along with kidney cancer such
as too few or too many red blood cells.
How is kidney cancer staged?
Staging is the process of finding out how far the cancer has
spread. It is very important because, to a large extent, treatment
and outlook for recovery depend on the stage of the cancer.
In general, the lower the number, the less the cancer has spread.
| Stage I |
The cancer has not spread and is only in
the kidney. |
| Stage II |
The cancer has spread to the fatty tissue
around the kidney, but not to the capsule around the kidney. |
| Stage III |
The cancer has spread to blood vessels or
lymph
nodes around the kidney. |
| Stage IV |
The cancer has spread to nearby organs (like
the bowel
or pancreas)
or to other places (like the lungs). |
Source: American Joint Committee on Cancer
Is kidney cancer fatal?
Prognosis for kidney cancer depends on how far the cancer has
spread. For early-stage cancer, the five-year
survival rate is 60 percent to 70 percent. If the cancer
has spread to the lymph nodes, the five-year survival rate is
5 percent to 15 percent. If it has spread to other organs, the
five-year survival rate is less than 5 percent.
How is kidney cancer treated?
Nephrectomy, or surgery to remove all or part of the
kidney, is the main treatment for renal cell carcinoma, although
a combination of treatments can be used. Tumor growth may be
controlled by arterial embolization, a procedure that
blocks the artery leading to the kidney to eliminate blood supply
to the tumor. Radiation
therapy may be used to reduce metastasis, although often
renal cell carcinoma does not respond well to this type of treatment.
In addition, hormonal
therapy, chemotherapy
and immunotherapy
may be used to treat this disease.
Below are additional resources that may be helpful to you.
Kidney
Cancer Association
Membership organization
of patients, family members, physicians and researchers |
National
Cancer Institute
Government agency providing
information and referrals |
American
Cancer Society
Programs of research, education,
patient service, advocacy, and rehabilitation |
Memorial
Sloan-Kettering Cancer Center World-renowned
cancer center dedicated to the prevention, treatment and
cure of cancer through patient care, research and education |
MEDLINEplus
Health Information Service of the National
Library of Information that provides information on conditions,
diseases and wellness, a medical encyclopedia and access
to consumer health libraries |
CancerCare Free counseling, education, information
and referral and direct financial assistance |
OncoLink
University of Pennsylvanias cancer resource providing
accurate cancer-related information |
CancerGuide
Information resource focusing on technical information
written by a former cancer patient |
Cancervive
Services for cancer patients, survivors and family members
dealing with the aftermath of the disease |
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